Squamous cell carcinoma - Skuamoz Hujayrali Karsinoma
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Squamous cell carcinoma well differentiated ― Qo'shni aktinik keratoz kuzatiladi.
References
Squamous cell carcinoma (SCC) Qo'shma Shtatlarda basal cell carcinoma dan keyin ikkinchi eng keng tarqalgan teri saratoni hisoblanadi. Odatda actinic keratosis deb ataladigan prekanseroz lezyonlardan boshlanadi va tananing boshqa qismlariga tarqalishi mumkin. Asosiy sabab quyoshning ultrabinafsha (UV) nurlanishining ta'siri bo'lib, vaqt o'tishi bilan to'planadi. Davolash odatda jarrohlik yo'li bilan olib tashlashni o'z ichiga oladi, ayniqsa bosh va bo'yin ustidagi SCC uchun. Radiatsiya terapiyasi keksa bemorlar yoki operatsiya qila olmaydiganlar uchun imkoniyatdir. Immunosupressiya SCC xavfini oshiradi. Kamdan kam bo'lsa-da, SCC tarqalishi mumkin, ayniqsa immuniteti zaif bemorlarda. SCC bo'lganlar uchun muntazam tekshiruvlar va quyoshdan himoyalanish muhim ahamiyatga ega.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) odamlarda ikkinchi eng keng tarqalgan saraton bo'lib, ularning soni ortib bormoqda. CSCC odatda yaxshi klinik xulq-atvorni namoyon qilsa-da, u mahalliy va tananing boshqa qismlariga tarqalishi mumkin. Olimlar yangi davolash usullariga olib keladigan CSCC rivojlanishining o'ziga xos yo'llarini aniqladilar. Mutatsiyalarning ko'pligi va immuniteti zaif bemorlarda xavfning ortishi immunoterapiyaning rivojlanishiga turtki bo'ldi. Ushbu sharhda CSCC ning genetik ildizlari va ma'lum molekulalar va immunitet tizimiga qaratilgan so'nggi davolash usullari ko'rib chiqiladi.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnoz va davolash
#Dermoscopy
#Skin biopsy